Part 5: Autonomic Pharmacology

The Autonomic Nervous System

The autonomic nervous system (ANS) controls involuntary functions including heart rate, blood pressure, digestion, and glandular secretion. Drugs targeting the ANS are among the most commonly prescribed medications, affecting sympathetic ("fight or flight") and parasympathetic ("rest and digest") pathways.

Topics in This Part

ANS Receptor Summary

Cholinergic (Parasympathetic)

  • M1-M5: Muscarinic (GPCRs)
  • Nm: Nicotinic muscle
  • Nn: Nicotinic neuronal

Adrenergic (Sympathetic)

  • α1: Vasoconstriction
  • α2: Presynaptic inhibition
  • β1: Cardiac stimulation
  • β2: Bronchodilation