Pharmacology
A comprehensive graduate-level course on pharmacology—from drug-receptor theory and pharmacokinetics through systems pharmacology, therapeutic areas, drug development, and pharmacogenomics.
Course Overview
Pharmacology is the science of how drugs interact with biological systems to produce therapeutic effects. This course covers the complete pipeline from molecular drug-receptor interactions and dose-response relationships through clinical pharmacology, drug development, and the emerging field of pharmacogenomics.
What You'll Learn
- • Drug-receptor theory and binding kinetics
- • Pharmacokinetics: ADME and compartment models
- • Pharmacodynamics and dose-response relationships
- • Autonomic and cardiovascular pharmacology
- • CNS pharmacology and antimicrobials
- • Anti-inflammatory, endocrine, and chemotherapy agents
- • Drug development and clinical trials
- • Pharmacogenomics and toxicology
Prerequisites
- • Biology and cell biology fundamentals
- • Organic chemistry and biochemistry
- • Physiology basics
- • Basic mathematics and statistics
- • Molecular biology (helpful)
Biochemistry
Enzymes, metabolism, and molecular machinery
Cell Physiology
Membrane transport, receptors, and cell signaling
Organic Chemistry
Drug structures, functional groups, and reactivity
Molecular Biology
Gene expression, protein synthesis, and regulation
References
- • H. P. Rang et al., Rang & Dale's Pharmacology (9th ed.)
- • L. L. Brunton et al., Goodman & Gilman's The Pharmacological Basis of Therapeutics
- • B. G. Katzung, Basic & Clinical Pharmacology
- • S. M. Stahl, Stahl's Essential Psychopharmacology
Ninja Nerd Pharmacology Library
Undergraduate-level companion videos from the Ninja Nerd Pharmacology series — antimicrobial, autonomic, cardiovascular, and CNS drug classes plus pharmacokinetic/pharmacodynamic foundations. Use as a clinical refresher before working through the quantitative parts of the course.
Pharmacokinetics & Pharmacodynamics
Drug Absorption
Drug Metabolism
Drug Distribution
Drug Excretion
Drug Clearance
Dosage Regimen
Pharmacodynamics
Antimicrobials
Antibiotics
Antivirals: HIV, Hepatitis, Influenza, Herpes
Antifungals
Antimycobacterials — Anti-TB Drugs
Autonomic Pharmacology
Cholinergic Agonists
Muscarinic Antagonists
Adrenergic Agonists
Adrenergic Antagonists
Cardiovascular Pharmacology
Antihypertensive Drugs
Antianginal Drugs
Antiarrhythmic Drugs
Antiplatelet, Anticoagulant & Thrombolytic Agents
Diuretics
CNS & Neurological Pharmacology
Anxiolytic & Hypnotic Drugs
Parkinson’s Disease Drugs
Migraine Medications
Course Structure
Part I: Foundations
Drug-receptor theory, pharmacokinetics, pharmacodynamics, and dose-response relationships.
Part II: Systems Pharmacology
Autonomic pharmacology, cardiovascular drugs, CNS pharmacology, and antimicrobials.
Part III: Therapeutic Areas
Anti-inflammatory agents, endocrine pharmacology, chemotherapy, and immunopharmacology.
Part IV: Drug Development
Drug development pipeline, clinical trials, pharmacogenomics, and toxicology.
Key Equations
Hill Equation
Sigmoidal dose-response with Hill coefficient n
Michaelis-Menten Kinetics
Enzyme kinetics: rate as a function of substrate concentration
Schild Plot
Determines antagonist affinity from dose ratios
One-Compartment Model
First-order elimination pharmacokinetics
Henderson-Hasselbalch
Determines ionization state affecting drug absorption
Emax Model
Hyperbolic concentration-effect relationship