Part 6: CNS Pharmacology

Drugs Acting on the Central Nervous System

CNS pharmacology encompasses drugs that treat psychiatric disorders, neurological diseases, and pain. These medications work by modulating neurotransmitter systems including GABA, glutamate, dopamine, serotonin, norepinephrine, and endogenous opioids.

Topics in This Part

Key Neurotransmitter Systems

GABA

Inhibitory; anxiolytics, sedatives

Glutamate

Excitatory; NMDA, AMPA

Dopamine

Reward, movement; antipsychotics

Serotonin

Mood; SSRIs, triptans

Norepinephrine

Arousal; SNRIs, TCAs

Endorphins

Pain modulation; opioids